The pulmonary metatranscriptome prior to pediatric HCT identifies post-HCT lung injury

UCB HCT in FLT3+ AML

Most common mutations in acute myeloid leukemia (AML) involving the FLT3 gene (FLT3+) are either internal tandem duplication (FLT3-ITD, 15% to 35%) or missense point mutations (5% to 10%) in the tyrosine kinase (TK) domain (TKD) [1]. FLT3+ AML has been recognized as a special subset with clinical characteristics (e.g., in younger patients, presenting with higher white blood cell count, and poor...

Hematopoietic cell transplantation (HCT)-specific comorbidity index: a new tool for risk assessment before allogeneic HCT.

We previously reported that the Charlson Comorbidity Index (CCI) was useful for predicting outcomes in patients undergoing allogeneic hematopoietic cell transplantation (HCT). However, the sample size of patients with scores of 1 or more, captured by the CCI, did not exceed 35%. Further, some comorbidities were rarely found among patients who underwent HCT. Therefore, the current study was desi...

Ferritin and FerriScan in HCT recipients.

Exforge HCT, INN-amlodipine + valsartan + hydrochlorothiazide

HCT survival in ADA-SCID: what's the buzz?

In this issue of Blood, Hassan et al have turned the spotlight on hematopoietic stem cell transplantation (HCT) of adenosine deaminase (ADA)-deficient severe combined immunodeficiency (SCID). They opened up the curtain of beliefs on this therapy that enables facts to be separated from fiction.